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White Papers / Tech Papers

Microspheres and Nanoparticles for Peptide Delivery

Navigating The Benefits And Challenges Of Microspheres And Nanoparticles For Peptide Delivery.

Released By Bachem

Executive Summary 
 

Proteins and peptides fulfill an irreplaceable role as medicines due to their high affinity, specificity, low toxicity, and ability to alter protein-protein interactions. They are widely recognized as therapeutic agents in the treatment of a variety of conditions, including diabetes, osteoporosis, non- Hodgkin’s lymphoma, and leukemia. Clinical development is on-going as the pharmaceutical industry works to harness the potential of peptides for many other conditions. While incredible progress has been made in designing peptide and protein-based drugs for multiple therapeutic uses, challenges remain. This paper explores challenges of peptide and protein-based new chemical entities [NCEs] including potential chemical and physical instabilities, enzymatic degradation, and their rapid elimination from circulation.

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